The following evidence tables (and additional evidence assessed where applicable) are available for download
Question 2: Does the use of risk stratified prediction tools (using clinical parameters) in patients with suspected TIA compared to not using risk stratified prediction tools accurately identify patients who are at high early stroke risk?
Question 3: For patients with ischaemic stroke with anterior circulation large vessel occlusion from 6-24 hours from last seen well, does mechanical thrombectomy plus best medical therapy improve functional outcome compared to best medical therapy alone?
Question 4: Which diagnostic investigations such as CT Angiography (CTA), MRI, MR Angiography (MRA) and Digital Subtraction Angiography (DSA), should be used and when in patients with acute intracerebral haemorrhage to detect a macrovascular abnormality?
Question 10: For eligible patients with ischaemic stroke and large vessel occlusion, does proceeding direct to mechanical thrombectomy improve functional outcome compared to thrombectomy plus intravenous thrombolysis (IVT) before?
Question 11: For patients with ischaemic stroke with basilar artery occlusion presenting either within 6 hours or between 6-24 hours of stroke onset, does mechanical thrombectomy in addition to best medical therapy improve functional outcome compared to best medical therapy alone?
Question 12: For patients with ischaemic stroke and large vessel occlusion, does thrombectomy performed under general anaesthesia improve outcome compared to local anaesthesia and/or conscious sedation?
Question 14: In patients with Novel Direct Oral Anticoagulant (NOAC) related acute intracerebral haemorrhage, do reversal methods (prothrombin complex concentrate-PCC, fresh frozen plasma –FFP, idarucizumab, andexanet alfa, tranexamic acid and Factor VIIa) improve functional outcome, mortality, haematoma expansion and normalise coagulation testing?
Question 17: What lipid-lowering treatments should be used in people who cannot tolerate statins, or in whom statins do not sufficiently lower cholesterol, after stroke or TIA? & Question 20: How low should LDL-C be lowered in secondary vascular prevention after stroke and TIA?
Question 19: For patients with ischaemic stroke and large vessel occlusion, does thrombectomy performed under general anaesthesia improve outcome compared to local anaesthesia and/or conscious sedation?
Question 42: Does assessment and treatment in Mobile Stroke Units (MSU) for suspected acute stroke patients in the out of hospital setting prior to arrival in hospital lead to better functional outcomes, improved thrombolysis and thrombectomy treatment rates with process times and improved survival compared with routine care?
Question 44: Is the use of MRI with DWI cost effective in identifying patients at high stroke risk compared with standard CT brain imaging in patients with suspected TIA? No table available – insufficient evidence.
Question 46 What should be the first-line imaging for acute stroke? No table available – addressed as a consensus question.
Question 47: What is the best treatment for post-stroke depression? Question 48: What is the best method to prevent post-stroke depression? Question 49: Do interventions aimed at treating anxiety after stroke improve outcomes?
Question 54: What is the effectiveness of intensive arm recovery programmes after stroke? No table available – insufficient evidence.